3FRG

Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor

3FRG の概要

• エントリーDOI: 10.2210/pdb3frg/pdb
• 関連するPDBエントリー: 1F0J
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 4-[(3-methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide, ZINC ION, ... (7 entities in total)
• 機能のキーワード: pde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41454.03

構造登録者

Somers, D.O.,Neu, M. (登録日: 2009-01-08, 公開日: 2010-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Lunniss, C.J.,Cooper, A.W.,Eldred, C.D.,Kranz, M.,Lindvall, M.,Lucas, F.S.,Neu, M.,Preston, A.G.,Ranshaw, L.E.,Redgrave, A.J.,Ed Robinson, J.,Shipley, T.J.,Solanke, Y.E.,Somers, D.O.,Wiseman, J.O.; Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.; Bioorg.Med.Chem.Lett., 19:1380-1385, 2009; PubMed: 19195882; DOI: 10.1016/j.bmcl.2009.01.045

実験手法

X-RAY DIFFRACTION (1.7 Å)