3FR5

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors

3FR5 の概要

• エントリーDOI: 10.2210/pdb3fr5/pdb
• 関連するPDBエントリー: 3FR2 3FR4
• 分子名称: Fatty acid-binding protein, adipocyte, 5-(3-carbamoylbenzyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylic acid (3 entities in total)
• 機能のキーワード: selective adipocyte fatty-acid binding protein (a-fabp) inhibitors, cytoplasm, lipid-binding, nucleus, phosphoprotein, polymorphism, transport, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15090
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14971.12

構造登録者

Barf, T.,Hammer, K.,Lehmann, F.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundb ck, T. (登録日: 2009-01-08, 公開日: 2009-03-10, 最終更新日: 2024-02-21)

• 主引用文献: Barf, T.,Lehmann, F.,Hammer, K.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundback, T.; N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors.; Bioorg.Med.Chem.Lett., 19:1745-1748, 2009; PubMed: 19217286; DOI: 10.1016/j.bmcl.2009.01.084

実験手法

X-RAY DIFFRACTION (2.2 Å)