3FPN

Crystal structure of UvrA-UvrB interaction domains

Summary for 3FPN

• Entry DOI: 10.2210/pdb3fpn/pdb
• Descriptor: Geobacillus stearothermophilus UvrA interaction domain, Geobacillus stearothermophilus UvrB interaction domain (3 entities in total)
• Functional Keywords: uvra, uvrb, nucleotide excision repair, dna repair, dna binding protein
• Biological source: Geobacillus stearothermophilus; More
• Total number of polymer chains: 2
• Total formula weight: 25710.46

Authors

Pakotiprapha, D.,Verdine, G.L.,Jeruzalmi, D. (deposition date: 2009-01-05, release date: 2009-03-24, Last modification date: 2023-09-06)

Primary citation

Pakotiprapha, D.,Liu, Y.,Verdine, G.L.,Jeruzalmi, D.
A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair.
J.Biol.Chem., 284:12837-12844, 2009

PubMed Abstract: Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA.UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.

PubMed: 19287003
DOI: 10.1074/jbc.M900571200

Experimental method

X-RAY DIFFRACTION (1.8 Å)