3FPN

Crystal structure of UvrA-UvrB interaction domains

3FPN の概要

• エントリーDOI: 10.2210/pdb3fpn/pdb
• 分子名称: Geobacillus stearothermophilus UvrA interaction domain, Geobacillus stearothermophilus UvrB interaction domain (3 entities in total)
• 機能のキーワード: uvra, uvrb, nucleotide excision repair, dna repair, dna binding protein
• 由来する生物種: Geobacillus stearothermophilus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25710.46

構造登録者

Pakotiprapha, D.,Verdine, G.L.,Jeruzalmi, D. (登録日: 2009-01-05, 公開日: 2009-03-24, 最終更新日: 2023-09-06)

主引用文献

Pakotiprapha, D.,Liu, Y.,Verdine, G.L.,Jeruzalmi, D.
A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair.
J.Biol.Chem., 284:12837-12844, 2009

PubMed Abstract: Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA.UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.

PubMed: 19287003
DOI: 10.1074/jbc.M900571200

実験手法

X-RAY DIFFRACTION (1.8 Å)