3FPD

G9a-like protein lysine methyltransferase inhibition by BIX-01294

3FPD の概要

• エントリーDOI: 10.2210/pdb3fpd/pdb
• 関連するPDBエントリー: 2RFI
• 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine, ... (5 entities in total)
• 機能のキーワード: epigenetics, histone lysine methylation, catalytic set domain, inhibition by bix-01294, alternative splicing, ank repeat, chromatin regulator, metal-binding, methyltransferase, nucleus, phosphoprotein, polymorphism, s-adenosyl-l-methionine, transferase, zinc
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9H9B1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62738.12

構造登録者

Chang, Y.,Zhang, X.,Horton, J.R.,Cheng, X. (登録日: 2009-01-05, 公開日: 2009-02-17, 最終更新日: 2023-09-06)

• 主引用文献: Chang, Y.,Zhang, X.,Horton, J.R.,Upadhyay, A.K.,Spannhoff, A.,Liu, J.,Snyder, J.P.,Bedford, M.T.,Cheng, X.; Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.; Nat.Struct.Mol.Biol., 16:312-317, 2009; PubMed: 19219047; DOI: 10.1038/nsmb.1560

実験手法

X-RAY DIFFRACTION (2.4 Å)