3FL9

Crystal structure of B. anthracis dihydrofolate reductase (DHFR) with trimethoprim

Summary for 3FL9

• Entry DOI: 10.2210/pdb3fl9/pdb
• Related: 2QK8 3E0B 3FL8
• Descriptor: dihydrofolate reductase (DHFR), CALCIUM ION, TRIMETHOPRIM, ... (4 entities in total)
• Functional Keywords: oxidoreductase, pyrimidine, dihydrophthalazine
• Biological source: Bacillus anthracis
• Total number of polymer chains: 8
• Total formula weight: 159566.79

Authors

Bourne, C.R.,Barrow, W.W. (deposition date: 2008-12-18, release date: 2009-04-28, Last modification date: 2023-09-06)

• Primary citation: Bourne, C.R.,Bunce, R.A.,Bourne, P.C.,Berlin, K.D.,Barrow, E.W.,Barrow, W.W.; Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.; Antimicrob.Agents Chemother., 53:3065-3073, 2009; PubMed: 19364848; DOI: 10.1128/AAC.01666-08

Experimental method

X-RAY DIFFRACTION (2.4 Å)