3FL0

X-ray structure of the non covalent swapped form of the Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE

3FL0 の概要

• エントリーDOI: 10.2210/pdb3fl0/pdb
• 関連するPDBエントリー: 1A2W 1BSR 1H8X 1TQ9 3BCP 3FKZ 3FL1 3FL3
• 分子名称: Ribonuclease pancreatic, 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: 3d-domain swapping, bovine seminal ribonuclease, non-covalent dimer, antitumor activity, quaternary structure flexibility, protein mutations and evolution, endonuclease, glycation, glycoprotein, hydrolase, nuclease, secreted
• 由来する生物種: Bos taurus (Bovine)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28151.39

構造登録者

Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F. (登録日: 2008-12-18, 公開日: 2009-03-24, 最終更新日: 2023-11-01)

• 主引用文献: Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F.; Toward an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three noncovalent dimeric mutants; Biopolymers, 91:1029-1037, 2009; PubMed: 19280639; DOI: 10.1002/bip.21183

実験手法

X-RAY DIFFRACTION (1.94 Å)