3FI3

Crystal structure of JNK3 with indazole inhibitor, SR-3737

3FI3 の概要

• エントリーDOI: 10.2210/pdb3fi3/pdb
• 関連するPDBエントリー: 3FI2
• 分子名称: Mitogen-activated protein kinase 10, 3-{5-[(2-fluorophenyl)amino]-1H-indazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: jnk3, protein-inhibitor complex, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42872.56

構造登録者

Habel, J.E.,Duckett, D.,LoGrasso, P. (登録日: 2008-12-10, 公開日: 2009-03-03, 最終更新日: 2023-09-06)

• 主引用文献: Kamenecka, T.,Habel, J.,Duckett, D.,Chen, W.,Ling, Y.Y.,Frackowiak, B.,Jiang, R.,Shin, Y.,Song, X.,LoGrasso, P.; Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.; J.Biol.Chem., 284:12853-12861, 2009; PubMed: 19261605; DOI: 10.1074/jbc.M809430200

実験手法

X-RAY DIFFRACTION (2.2 Å)