3FHB
Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid
Replaces: 2PA9Summary for 3FHB
Entry DOI | 10.2210/pdb3fhb/pdb |
Descriptor | Poly [ADP-ribose] polymerase 3, 3-AMINOBENZOIC ACID (3 entities in total) |
Functional Keywords | transferase, enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, alternative splicing, glycosyltransferase, nad, nucleus |
Biological source | Homo sapiens |
Cellular location | Nucleus: Q9Y6F1 |
Total number of polymer chains | 1 |
Total formula weight | 39889.21 |
Authors | Lehtio, L.,Karlberg, T.,Arrowsmith, C.H.,Berglund, H.,Busam, R.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Johansson, I.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Schueler, H.,Stenmark, P.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2008-12-09, release date: 2009-01-06, Last modification date: 2024-02-21) |
Primary citation | Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J.Med.Chem., 52:3108-3111, 2009 Cited by PubMed: 19354255DOI: 10.1021/jm900052j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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