3FFP

X ray structure of the complex between carbonic anhydrase II and LC inhibitors

3FFP の概要

• エントリーDOI: 10.2210/pdb3ffp/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29957.51

構造登録者

Temperini, C.,Crocetti, L.,Scozzafava, A.,Supuran, C.T. (登録日: 2008-12-04, 公開日: 2009-08-18, 最終更新日: 2023-11-01)

• 主引用文献: Crocetti, L.,Maresca, A.,Temperini, C.,Hall, R.A.,Scozzafava, A.,Muhlschlegel, F.A.,Supuran, C.T.; A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases; Bioorg.Med.Chem.Lett., 19:1371-1375, 2009; PubMed: 19186056; DOI: 10.1016/j.bmcl.2009.01.038

実験手法

X-RAY DIFFRACTION (1.81 Å)