3FFI

HIV-1 RT with pyridone non-nucleoside inhibitor

3FFI の概要

• エントリーDOI: 10.2210/pdb3ffi/pdb
• 関連するPDBエントリー: 3di6 3dya 3e01
• 分子名称: Reverse transcriptase/ribonuclease H, RT p51, 3-chloro-5-({6-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-3-(dimethylamino)-2-oxo-1,2-dihydropyridin-4-yl}oxy)benzonitrile, ... (4 entities in total)
• 機能のキーワード: hiv, rt, reverse transcriptase, transferase rna-directed dna polymerase, nucleotidyltransferase, aids, cytoplasm, transferase, viral nucleoprotein, hydrolase
• 由来する生物種: HIV-1 M:B_HXB2R (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116687.31

構造登録者

Harris, S.F.,Villasenor, A. (登録日: 2008-12-03, 公開日: 2009-12-15, 最終更新日: 2024-02-21)

• 主引用文献: Kennedy-Smith, J.,Sweeney, Z.K.; Pyridone Diaryl Ether Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase; To be Published,

実験手法

X-RAY DIFFRACTION (2.6 Å)