3FFG
Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE
3FFG の概要
エントリーDOI | 10.2210/pdb3ffg/pdb |
分子名称 | Coagulation factor X, heavy chain, Coagulation factor X, light chain, (R)-6-(2'-((3-hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin-7(4h)-one, ... (4 entities in total) |
機能のキーワード | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, calcium, cleavage on pair of basic residues, protease, secreted |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Secreted: P00742 P00742 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 32651.94 |
構造登録者 | |
主引用文献 | Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett., 20:1373-1377, 2010 Cited by PubMed: 20100660DOI: 10.1016/j.bmcl.2010.01.011 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.54 Å) |
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