3FFD

Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody

3FFD の概要

• エントリーDOI: 10.2210/pdb3ffd/pdb
• 分子名称: Monoclonal antibody, heavy chain, Fab fragment, Monoclonal antibody, light chain, Fab fragment, Parathyroid hormone-related protein, ... (4 entities in total)
• 機能のキーワード: pthrp complexed to fab, cleavage on pair of basic residues, hormone, nucleus, secreted, immune system-hormone complex, immune system/hormone
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Cytoplasm: P12272
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 59688.98

構造登録者

Mckinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W. (登録日: 2008-12-03, 公開日: 2009-04-28, 最終更新日: 2023-11-01)

• 主引用文献: McKinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W.; Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor; J.Biol.Chem., 284:15557-15563, 2009; PubMed: 19346515; DOI: 10.1074/jbc.M900044200

実験手法

X-RAY DIFFRACTION (2 Å)