3FEI
Design and biological evaluation of novel, balanced dual PPARa/g agonists
Summary for 3FEI
Entry DOI | 10.2210/pdb3fei/pdb |
Related | 3FEJ |
Descriptor | Peroxisome proliferator-activated receptor alpha, Peptide motif 5 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, diabetes, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32363.25 |
Authors | Benz, J.,Grether, U.,Gsell, B.,Binggeli, A.,Hilpert, H.,Maerki, H.P.,Mohr, P.,Ruf, A.,Stihle, M.,Schlatter, D. (deposition date: 2008-11-30, release date: 2009-10-20, Last modification date: 2023-12-27) |
Primary citation | Grether, U.,Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Hilpert, H.,Kuhn, B.,Maerki, H.P.,Meyer, M.,Mohr, P.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D. Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists Chemmedchem, 4:951-956, 2009 Cited by PubMed: 19326383DOI: 10.1002/cmdc.200800425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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