3FEI

Design and biological evaluation of novel, balanced dual PPARa/g agonists

3FEI の概要

• エントリーDOI: 10.2210/pdb3fei/pdb
• 関連するPDBエントリー: 3FEJ
• 分子名称: Peroxisome proliferator-activated receptor alpha, Peptide motif 5 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, diabetes, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q07869; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32363.25

構造登録者

Benz, J.,Grether, U.,Gsell, B.,Binggeli, A.,Hilpert, H.,Maerki, H.P.,Mohr, P.,Ruf, A.,Stihle, M.,Schlatter, D. (登録日: 2008-11-30, 公開日: 2009-10-20, 最終更新日: 2023-12-27)

• 主引用文献: Grether, U.,Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Hilpert, H.,Kuhn, B.,Maerki, H.P.,Meyer, M.,Mohr, P.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D.; Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists; Chemmedchem, 4:951-956, 2009; PubMed: 19326383; DOI: 10.1002/cmdc.200800425

実験手法

X-RAY DIFFRACTION (2.4 Å)