3FDE

Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution

3FDE の概要

• エントリーDOI: 10.2210/pdb3fde/pdb
• 関連するPDBエントリー: 2ZO0 2ZO1 2ZO2 3F8I 3F8J
• 分子名称: E3 ubiquitin-protein ligase UHRF1, 5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', ... (7 entities in total)
• 機能のキーワード: sra domain, base flipping, dna cpg methylation, cell cycle, developmental protein, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger
• 由来する生物種: Mus musculus; 詳細
• 細胞内の位置: Nucleus: Q8VDF2
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 63970.50

構造登録者

Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X. (登録日: 2008-11-25, 公開日: 2009-01-06, 最終更新日: 2023-12-27)

• 主引用文献: Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X.; UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.; Epigenetics, 4:8-14, 2009; PubMed: 19077538

実験手法

X-RAY DIFFRACTION (1.41 Å)