3FC1

Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor

3FC1 の概要

• エントリーDOI: 10.2210/pdb3fc1/pdb
• 分子名称: Mitogen-activated protein kinase 14, CHLORIDE ION, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42470.65

構造登録者

Jacobs, M.D.,Bellon, S. (登録日: 2008-11-20, 公開日: 2008-12-09, 最終更新日: 2023-12-27)

• 主引用文献: Pearlman, D.A.; Evaluating the molecular mechanics poisson-boltzmann surface area free energy method using a congeneric series of ligands to p38 MAP kinase.; J.Med.Chem., 48:7796-7807, 2005; PubMed: 16302819; DOI: 10.1021/jm050306m

実験手法

X-RAY DIFFRACTION (2.4 Å)