3FBV

Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1

Summary for 3FBV

• Entry DOI: 10.2210/pdb3fbv/pdb
• Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1, N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine (2 entities in total)
• Functional Keywords: ire1, rnase, ribonuclease, complex, kinase, inhibitor, oligomer, cytoplasmic, apy29, aminopyrazole, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
• Biological source: Saccharomyces cerevisiae
• Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
• Total number of polymer chains: 14
• Total formula weight: 731020.56

Authors

Korennykh, A.V.,Egea, P.F.,Korostelev, A.A.,Finer-Moore, J.,Zhang, C.,Shokat, K.M.,Stroud, R.M.,Walter, P. (deposition date: 2008-11-19, release date: 2008-12-16, Last modification date: 2023-09-06)

• Primary citation: Korennykh, A.V.,Egea, P.F.,Korostelev, A.A.,Finer-Moore, J.,Zhang, C.,Shokat, K.M.,Stroud, R.M.,Walter, P.; The unfolded protein response signals through high-order assembly of Ire1.; Nature, 457:687-693, 2009; PubMed: 19079236; DOI: 10.1038/nature07661

Experimental method

X-RAY DIFFRACTION (3.2 Å)