3FBV

Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1

3FBV の概要

• エントリーDOI: 10.2210/pdb3fbv/pdb
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine (2 entities in total)
• 機能のキーワード: ire1, rnase, ribonuclease, complex, kinase, inhibitor, oligomer, cytoplasmic, apy29, aminopyrazole, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
• 由来する生物種: Saccharomyces cerevisiae
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 731020.56

構造登録者

Korennykh, A.V.,Egea, P.F.,Korostelev, A.A.,Finer-Moore, J.,Zhang, C.,Shokat, K.M.,Stroud, R.M.,Walter, P. (登録日: 2008-11-19, 公開日: 2008-12-16, 最終更新日: 2023-09-06)

• 主引用文献: Korennykh, A.V.,Egea, P.F.,Korostelev, A.A.,Finer-Moore, J.,Zhang, C.,Shokat, K.M.,Stroud, R.M.,Walter, P.; The unfolded protein response signals through high-order assembly of Ire1.; Nature, 457:687-693, 2009; PubMed: 19079236; DOI: 10.1038/nature07661

実験手法

X-RAY DIFFRACTION (3.2 Å)