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3FBA

Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand

Summary for 3FBA
Entry DOI10.2210/pdb3fba/pdb
Descriptor2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, [(2S,3S,4R,5S)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ... (6 entities in total)
Functional Keywordsmecdp-synthase, lyase, isoprene biosynthesis, magnesium, manganese, metal-binding
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight18371.18
Authors
Hunter, W.N.,Ramsden, N.L. (deposition date: 2008-11-19, release date: 2009-08-25, Last modification date: 2023-11-01)
Primary citationRamsden, N.L.,Buetow, L.,Dawson, A.,Kemp, L.A.,Ulaganathan, V.,Brenk, R.,Klebe, G.,Hunter, W.N.
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52:2531-2542, 2009
Cited by
PubMed: 19320487
DOI: 10.1021/jm801475n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217705

건을2024-03-27부터공개중

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