3FAA

Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor

Summary for 3FAA

Entry DOI	10.2210/pdb3faa/pdb
Descriptor	TGF-beta receptor type-1, N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide, PHOSPHATE ION (3 entities in total)
Functional Keywords	kinase, tgfbeta, structure-based drug design, protein-inhibitor complex, atp-binding, craniosynostosis, disease mutation, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, receptor, serine/threonine-protein kinase, transferase, transmembrane
Biological source	Homo sapiens
Cellular location	Cell membrane ; Single-pass type I membrane protein : P36897
Total number of polymer chains	5
Total formula weight	197649.63
Authors	Boriack-Sjodin, P.A.,Fitch, C. (deposition date: 2008-11-16, release date: 2009-01-27, Last modification date: 2023-12-27)
Primary citation	Bonafoux, D.,Chuaqui, C.,Boriack-Sjodin, P.A.,Fitch, C.,Hankins, G.,Josiah, S.,Black, C.,Hetu, G.,Ling, L.,Lee, W.C. 2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg.Med.Chem.Lett., 19:912-916, 2009 Cited by PubMed: 19135364 DOI: 10.1016/j.bmcl.2008.11.119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation