3FAA

Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor

3FAA の概要

• エントリーDOI: 10.2210/pdb3faa/pdb
• 分子名称: TGF-beta receptor type-1, N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: kinase, tgfbeta, structure-based drug design, protein-inhibitor complex, atp-binding, craniosynostosis, disease mutation, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, receptor, serine/threonine-protein kinase, transferase, transmembrane
• 由来する生物種: Homo sapiens
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P36897
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 197649.63

構造登録者

Boriack-Sjodin, P.A.,Fitch, C. (登録日: 2008-11-16, 公開日: 2009-01-27, 最終更新日: 2023-12-27)

• 主引用文献: Bonafoux, D.,Chuaqui, C.,Boriack-Sjodin, P.A.,Fitch, C.,Hankins, G.,Josiah, S.,Black, C.,Hetu, G.,Ling, L.,Lee, W.C.; 2-Aminoimidazoles inhibitors of TGF-beta receptor 1.; Bioorg.Med.Chem.Lett., 19:912-916, 2009; PubMed: 19135364; DOI: 10.1016/j.bmcl.2008.11.119

実験手法

X-RAY DIFFRACTION (3.35 Å)