3F97

Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by soman

3F97 の概要

• エントリーDOI: 10.2210/pdb3f97/pdb
• 関連するPDBエントリー: 3D59 3D5E 3F96 3F98 3F9C
• 分子名称: Platelet-activating factor acetylhydrolase, (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: plasma platelet-activating factor acetylhydrolase, secreted protein, alpha/beta-hydrolase-fold, ldl-bound; lipoprotein associated phospholipase a2, lp-pla2, group viia pla2, glycoprotein, hydrolase, lipid degradation, polymorphism, soman, disease mutation, secreted
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted, extracellular space: Q13093
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87590.29

構造登録者

Samanta, U.,Bahnson, B.J. (登録日: 2008-11-13, 公開日: 2009-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Samanta, U.,Kirby, S.D.,Srinivasan, P.,Cerasoli, D.M.,Bahnson, B.J.; Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.; Biochem Pharmacol, 78:420-429, 2009; PubMed: 19394314; DOI: 10.1016/j.bcp.2009.04.018

実験手法

X-RAY DIFFRACTION (1.7 Å)