3F8S

Crystal structure of dipeptidyl peptidase IV in complex with inhibitor

3F8S の概要

• エントリーDOI: 10.2210/pdb3f8s/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: dipeptidyl peptidase 4, complex, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 176391.89

構造登録者

Ammirati, M.J.,Liu, S.,Piotrowski, D.W. (登録日: 2008-11-13, 公開日: 2009-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Ammirati, M.J.,Andrews, K.M.,Boyer, D.D.,Brodeur, A.M.,Danley, D.E.,Doran, S.D.,Hulin, B.,Liu, S.,McPherson, R.K.,Orena, S.J.,Parker, J.C.,Polivkova, J.,Qiu, X.,Soglia, C.B.,Treadway, J.L.,VanVolkenburg, M.A.,Wilder, D.C.,Piotrowski, D.W.; (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.; Bioorg.Med.Chem.Lett., 19:1991-1995, 2009; PubMed: 19275964; DOI: 10.1016/j.bmcl.2009.02.041

実験手法

X-RAY DIFFRACTION (2.43 Å)