Crystal Structure of the R132K:R111L:L121E:R59W Mutant of Cellular Retinoic Acid-Binding Protein Type II Complexed with C15-aldehyde (a retinal analog) at 1.95 Angstrom resolution.

Summary for 3F8A

Related3F9D 3CR6 3FA6 3FA7 3FA8 3FA9
DescriptorCellular retinoic acid-binding protein 2, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene, ... (4 entities in total)
Functional Keywordscrabpii, retinal, protonated schiff base, c15-aldehyde, retinoic acid, retinoid, nucleus, retinol-binding, transport, vitamin a, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P29373
Total number of polymer chains1
Total molecular weight16041.41
Jia, X.,Geiger, J.H. (deposition date: 2008-11-12, release date: 2009-11-10, Last modification date: 2016-12-28)
Primary citation
Lee, K.S.,Berbasova, T.,Vasileiou, C.,Jia, X.,Wang, W.,Choi, Y.,Nossoni, F.,Geiger, J.H.,Borhan, B.
Probing Wavelength Regulation with an Engineered Rhodopsin Mimic and a C15-Retinal Analogue
Chempluschem, 77:273-276, 2012
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2621401.6%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution