3F82
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Summary for 3F82
Entry DOI | 10.2210/pdb3f82/pdb |
Descriptor | hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total) |
Functional Keywords | alternative splicing, receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35947.92 |
Authors | Sack, J. (deposition date: 2008-11-11, release date: 2009-03-31, Last modification date: 2024-04-03) |
Primary citation | Schroeder, G.M.,An, Y.,Cai, Z.W.,Chen, X.T.,Clark, C.,Cornelius, L.A.,Dai, J.,Gullo-Brown, J.,Gupta, A.,Henley, B.,Hunt, J.T.,Jeyaseelan, R.,Kamath, A.,Kim, K.,Lippy, J.,Lombardo, L.J.,Manne, V.,Oppenheimer, S.,Sack, J.S.,Schmidt, R.J.,Shen, G.,Stefanski, K.,Tokarski, J.S.,Trainor, G.L.,Wautlet, B.S.,Wei, D.,Williams, D.K.,Zhang, Y.,Zhang, Y.,Fargnoli, J.,Borzilleri, R.M. Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily J.Med.Chem., 52:1251-1254, 2009 Cited by PubMed: 19260711DOI: 10.1021/jm801586s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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