3F81
Interaction of VHR with SA3
Summary for 3F81
Entry DOI | 10.2210/pdb3f81/pdb |
Descriptor | Dual specificity protein phosphatase 3, 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid (3 entities in total) |
Functional Keywords | hydrolase, protein dual-specificity phosphatase, inhibitor, protein phosphatase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 41729.32 |
Authors | Wu, S.,Mutelin, T.,Tautz, L. (deposition date: 2008-11-11, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Wu, S.,Vossius, S.,Rahmouni, S.,Miletic, A.V.,Vang, T.,Vazquez-Rodriguez, J.,Cerignoli, F.,Arimura, Y.,Williams, S.,Hayes, T.,Moutschen, M.,Vasile, S.,Pellecchia, M.,Mustelin, T.,Tautz, L. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J.Med.Chem., 52:6716-6723, 2009 Cited by PubMed: 19888758DOI: 10.1021/jm901016k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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