3F81

Interaction of VHR with SA3

3F81 の概要

• エントリーDOI: 10.2210/pdb3f81/pdb
• 分子名称: Dual specificity protein phosphatase 3, 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid (3 entities in total)
• 機能のキーワード: hydrolase, protein dual-specificity phosphatase, inhibitor, protein phosphatase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41729.32

構造登録者

Wu, S.,Mutelin, T.,Tautz, L. (登録日: 2008-11-11, 公開日: 2009-11-10, 最終更新日: 2023-09-06)

• 主引用文献: Wu, S.,Vossius, S.,Rahmouni, S.,Miletic, A.V.,Vang, T.,Vazquez-Rodriguez, J.,Cerignoli, F.,Arimura, Y.,Williams, S.,Hayes, T.,Moutschen, M.,Vasile, S.,Pellecchia, M.,Mustelin, T.,Tautz, L.; Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.; J.Med.Chem., 52:6716-6723, 2009; PubMed: 19888758; DOI: 10.1021/jm901016k

実験手法

X-RAY DIFFRACTION (1.9 Å)