3F7T

Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre

3F7T の概要

• エントリーDOI: 10.2210/pdb3f7t/pdb
• 分子名称: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PYROPHOSPHATE 2-, ... (5 entities in total)
• 機能のキーワード: pseudo-c3-symmetry; unprecedent fold for fes-cluster proteins, iron, iron-sulfur, isoprene biosynthesis, metal-binding, nadp, oxidoreductase, protein binding
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74149.34

構造登録者

Graewert, T.,Eppinger, J.,Rohdich, F.,Bacher, A.,Eisenreich, W.,Groll, M. (登録日: 2008-11-10, 公開日: 2009-07-07, 最終更新日: 2023-12-27)

• 主引用文献: Grawert, T.,Rohdich, F.,Span, I.,Bacher, A.,Eisenreich, W.,Eppinger, J.,Groll, M.; Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction.; Angew.Chem.Int.Ed.Engl., 48:5756-5759, 2009; PubMed: 19569147; DOI: 10.1002/anie.200900548

実験手法

X-RAY DIFFRACTION (1.8 Å)