3F75

Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide

Summary for 3F75

Entry DOI	10.2210/pdb3f75/pdb
Descriptor	Cathepsin L Protease, Cathepsin L Propeptide, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	medical structural genomics of pathogenic protozoa, msgpp, cysteine protease, parasite, protozoa, hydrolase, thiol protease
Biological source	Toxoplasma gondii More
Total number of polymer chains	2
Total formula weight	37435.75
Authors	Larson, E.T.,Merritt, E.A.,Medical Structural Genomics of Pathogenic Protozoa (MSGPP) (deposition date: 2008-11-07, release date: 2008-11-25, Last modification date: 2023-09-06)
Primary citation	Larson, E.T.,Parussini, F.,Huynh, M.H.,Giebel, J.D.,Kelley, A.M.,Zhang, L.,Bogyo, M.,Merritt, E.A.,Carruthers, V.B. Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl. J.Biol.Chem., 284:26839-26850, 2009 Cited by PubMed: 19596863 DOI: 10.1074/jbc.M109.003780 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation