3F6X

c-Src kinase domain in complex with small molecule inhibitor

3F6X の概要

• エントリーDOI: 10.2210/pdb3f6x/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile (3 entities in total)
• 機能のキーワード: kinase, atp-binding, alternative splicing, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cell membrane (By similarity): P00523
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132432.31

構造登録者

Seeliger, M.A.,Statsuk, A.V.,Maly, D.J.,Patrick, P.Z.,Kuriyan, J.,Shokat, K.M. (登録日: 2008-11-06, 公開日: 2008-12-09, 最終更新日: 2023-09-06)

• 主引用文献: Statsuk, A.V.,Maly, D.J.,Seeliger, M.A.,Fabian, M.A.,Biggs, W.H.,Lockhart, D.J.,Zarrinkar, P.P.,Kuriyan, J.,Shokat, K.M.; Tuning a three-component reaction for trapping kinase substrate complexes.; J.Am.Chem.Soc., 130:17568-17574, 2008; PubMed: 19053485; DOI: 10.1021/ja807066f

実験手法

X-RAY DIFFRACTION (2.35 Å)