3F69

Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

3F69 の概要

• エントリーDOI: 10.2210/pdb3f69/pdb
• 分子名称: Serine/threonine-protein kinase pknB, hexyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8-tetrahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]c yclopenta[e]-as-indacene-6-carboxylate, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase, pknb, mycobacterium tuberculosis, kt5720, structural genomics, structual genomics, cocrystallization of pknb kinase domain and inhibitors, tb structural genomics consortium, tbsgc, atp-binding, kinase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68556.40

構造登録者

Alber, T.,Mieczkowski, C.A.,TB Structural Genomics Consortium (TBSGC) (登録日: 2008-11-05, 公開日: 2008-12-02, 最終更新日: 2024-04-03)

• 主引用文献: Mieczkowski, C.,Iavarone, A.T.,Alber, T.; Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.; Embo J., 27:3186-3197, 2008; PubMed: 19008858; DOI: 10.1038/emboj.2008.236

実験手法

X-RAY DIFFRACTION (2.8 Å)