3F66

Human c-Met Kinase in complex with quinoxaline inhibitor

3F66 の概要

• エントリーDOI: 10.2210/pdb3f66/pdb
• 分子名称: Hepatocyte growth factor receptor, 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, ... (5 entities in total)
• 機能のキーワード: c-met, protein kinase, quinoxaline, alternative splicing; atp-binding; chromosomal rearrangement; disease mutation; glycoprotein; kinase; membrane; nucleotide-binding; phosphoprotein; polymorphism; proto-oncogene; receptor; repeat; signal; transferase; transmembrane; tyrosine-protein kinase., transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68920.69

構造登録者

Meier, C.,Ceska, T. (登録日: 2008-11-05, 公開日: 2008-12-23, 最終更新日: 2023-12-27)

• 主引用文献: Porter, J.,Lumb, S.,Lecomte, F.,Reuberson, J.,Foley, A.,Calmiano, M.,le Riche, K.,Edwards, H.,Delgado, J.,Franklin, R.J.,Gascon-Simorte, J.M.,Maloney, A.,Meier, C.,Batchelor, M.; Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.; Bioorg.Med.Chem.Lett., 19:397-400, 2009; PubMed: 19059779; DOI: 10.1016/j.bmcl.2008.11.062

実験手法

X-RAY DIFFRACTION (1.4 Å)