3F2N

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

3F2N の概要

• エントリーDOI: 10.2210/pdb3f2n/pdb
• 分子名称: Serine/threonine-protein kinase haspin, (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: haspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q8TF76
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41428.18

構造登録者

Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Yue, W.W.,Murray, J.W.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2008-10-30, 公開日: 2008-12-02, 最終更新日: 2023-11-01)

• 主引用文献: Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Yue, W.W.,Murray, J.W.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.; Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand; To be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)