3F1Z

Crystal structure of putative nucleic acid-binding lipoprotein (YP_001337197.1) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 2.46 A resolution

Summary for 3F1Z

• Entry DOI: 10.2210/pdb3f1z/pdb
• Descriptor: putative nucleic acid-binding lipoprotein, DI(HYDROXYETHYL)ETHER (3 entities in total)
• Functional Keywords: yp_001337197.1, putative nucleic acid-binding lipoprotein, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, unknown function, dna binding protein
• Biological source: Klebsiella pneumoniae subsp. pneumoniae MGH 78578
• Total number of polymer chains: 10
• Total formula weight: 146223.23

Authors

Joint Center for Structural Genomics (JCSG) (deposition date: 2008-10-28, release date: 2008-11-18, Last modification date: 2024-10-30)

Primary citation

Das, D.,Kozbial, P.,Han, G.W.,Carlton, D.,Jaroszewski, L.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Bakolitsa, C.,Chen, C.,Chiu, H.J.,Chiu, M.,Clayton, T.,Deller, M.C.,Duan, L.,Ellrott, K.,Elsliger, M.A.,Ernst, D.,Farr, C.L.,Feuerhelm, J.,Grzechnik, A.,Grant, J.C.,Jin, K.K.,Johnson, H.A.,Klock, H.E.,Knuth, M.W.,Krishna, S.S.,Kumar, A.,Marciano, D.,McMullan, D.,Miller, M.D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Oommachen, S.,Paulsen, J.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Wooten, T.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold.
Acta Crystallogr.,Sect.F, 66:1254-1260, 2010

PubMed Abstract: KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family.

PubMed: 20944219
DOI: 10.1107/S1744309109018168

Experimental method

X-RAY DIFFRACTION (2.46 Å)