3F0T

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

Summary for 3F0T

Entry DOI	10.2210/pdb3f0t/pdb
Related	1E2H 1E2P
Descriptor	Thymidine kinase, SULFATE ION, N-Methyl-6-(1,3-dihydroxy-isobutyl)thymine, ... (4 entities in total)
Functional Keywords	transferase, thymidine kinase, dna-synthesis, pet tracer, atp-binding, dna synthesis, early protein, nucleotide-binding
Biological source	Herpes simplex virus (type 1 / strain 17) (virus)
Total number of polymer chains	2
Total formula weight	72849.40
Authors	Pernot, L.,Perozzo, R.,Westermaier, Y.,Martic, M.,Ametamey, S.,Scapozza, L. (deposition date: 2008-10-26, release date: 2009-11-03, Last modification date: 2023-09-06)
Primary citation	Martic, M.,Pernot, L.,Westermaier, Y.,Perozzo, R.,Kraljevic, T.G.,Kristafor, S.,Raic-Malic, S.,Scapozza, L.,Ametamey, S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids, 30:293-315, 2011 Cited by PubMed: 21623543 DOI: 10.1080/15257770.2011.581258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation