3EYV

Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions

Summary for 3EYV

• Entry DOI: 10.2210/pdb3eyv/pdb
• Related: 1S3K
• Related PRD ID: PRD_900124
• Descriptor: hu3S193 Fab, light chain, hu3S193 Fab, heavy chain, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: immunoglobulin fold, beta barrel, humanized antibody, antigen binding fragment, immune system
• Biological source: MUS MUSCULUS (mouse); More
• Total number of polymer chains: 4
• Total formula weight: 96756.05

Authors

Farrugia, W.,Scott, A.M.,Ramsland, P.A. (deposition date: 2008-10-22, release date: 2009-11-03, Last modification date: 2024-10-09)

Primary citation

Farrugia, W.,Scott, A.M.,Ramsland, P.A.
A possible role for metallic ions in the carbohydrate cluster recognition displayed by a lewis y specific antibody.
Plos One, 4:e7777-e7777, 2009

PubMed Abstract: Lewis Y (Le(y)) is a blood group-related carbohydrate that is expressed at high surface densities on the majority of epithelial carcinomas and is a promising target for antibody-based immunotherapy. A humanized Le(y)-specific antibody (hu3S193) has shown encouraging safety, pharmacokinetic and tumor-targeting properties in recently completed Phase I clinical trials.

PubMed: 19901987
DOI: 10.1371/journal.pone.0007777

Experimental method

X-RAY DIFFRACTION (2.5 Å)