3EYD

Structure of HCV NS3-4A Protease with an Inhibitor Derived from a Boronic Acid

Summary for 3EYD

Entry DOI	10.2210/pdb3eyd/pdb
Descriptor	HCV NS3, HCV NS4a peptide, ZINC ION, ... (5 entities in total)
Functional Keywords	hepatitis c virus, ns3 protease domain, serine protease, boronic acid inhibitor, envelope protein, helicase, hydrolase, nucleotide-binding, rna replication, transmembrane, viral protein
Biological source	Hepatitis C virus subtype 1a More
Total number of polymer chains	4
Total formula weight	48012.99
Authors	Venkatraman, S.,Wu, W.,Prongay, A.J.,Girijavallabhan, V.,Njoroge, F.G. (deposition date: 2008-10-20, release date: 2009-02-10, Last modification date: 2024-04-03)
Primary citation	Venkatraman, S.,Wu, W.,Prongay, A.,Girijavallabhan, V.,George Njoroge, F. Potent inhibitors of HCV-NS3 protease derived from boronic acids. Bioorg.Med.Chem.Lett., 19:180-183, 2009 Cited by PubMed: 19022670 DOI: 10.1016/j.bmcl.2008.10.124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation