3EYD
Structure of HCV NS3-4A Protease with an Inhibitor Derived from a Boronic Acid
Summary for 3EYD
Entry DOI | 10.2210/pdb3eyd/pdb |
Descriptor | HCV NS3, HCV NS4a peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | hepatitis c virus, ns3 protease domain, serine protease, boronic acid inhibitor, envelope protein, helicase, hydrolase, nucleotide-binding, rna replication, transmembrane, viral protein |
Biological source | Hepatitis C virus subtype 1a More |
Total number of polymer chains | 4 |
Total formula weight | 48012.99 |
Authors | Venkatraman, S.,Wu, W.,Prongay, A.J.,Girijavallabhan, V.,Njoroge, F.G. (deposition date: 2008-10-20, release date: 2009-02-10, Last modification date: 2024-04-03) |
Primary citation | Venkatraman, S.,Wu, W.,Prongay, A.,Girijavallabhan, V.,George Njoroge, F. Potent inhibitors of HCV-NS3 protease derived from boronic acids. Bioorg.Med.Chem.Lett., 19:180-183, 2009 Cited by PubMed: 19022670DOI: 10.1016/j.bmcl.2008.10.124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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