3EXG

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Summary for 3EXG

Entry DOI	10.2210/pdb3exg/pdb
Related	3EXE 3EXF 3EXH 3EXI
Descriptor	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, POTASSIUM ION (3 entities in total)
Functional Keywords	heterotetramer; thiamine diphosphate-dependent enzyme; disease mutation; glycolysis; leigh syndrome; mitochondrion; oxidoreductase; phosphoprotein; alternative splicing; polymorphism; pyruvate; thiamine pyrophosphate; transit peptide, oxidoreductase
Biological source	Homo sapiens (human) More
Cellular location	Mitochondrion matrix: P08559 P11177
Total number of polymer chains	32
Total formula weight	1256526.88
Authors	Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.-C.,Machius, M.,Li, J.,Chuang, D.T. (deposition date: 2008-10-16, release date: 2008-11-25, Last modification date: 2023-12-27)
Primary citation	Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.C.,Machius, M.,Li, J.,Chuang, D.T. Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure, 16:1849-1859, 2008 Cited by PubMed: 19081061 DOI: 10.1016/j.str.2008.10.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.011 Å)

Structure validation