3EWH

Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor

3EWH の概要

• エントリーDOI: 10.2210/pdb3ewh/pdb
• 関連するPDBエントリー: 3EFW
• 分子名称: vascular endothelial growth factor receptor 2, N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: angiogenesis, receptor tyrosine kinase, dfg-out, transferase
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36714.20

構造登録者

Whittington, D.A.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (登録日: 2008-10-15, 公開日: 2009-08-25, 最終更新日: 2023-12-27)

• 主引用文献: Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bak, A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Fretland, J.,Gu, Y.,Hodous, B.L.,Huang, X.,Kim, J.L.,Lin, J.,Long, A.M.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Zhou, Y.,Hughes, P.,Geuns-Meyer, S.; Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.; Bioorg.Med.Chem.Lett., 19:424-427, 2009; PubMed: 19062275; DOI: 10.1016/j.bmcl.2008.11.056

実験手法

X-RAY DIFFRACTION (1.6 Å)