3EVC
Crystal structure of GTP complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine
3EVC の概要
エントリーDOI | 10.2210/pdb3evc/pdb |
関連するPDBエントリー | 3EVA 3EVB 3EVD 3EVE 3EVF 3EVG |
分子名称 | RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE, GUANOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
機能のキーワード | yellow fever virus, ns5 methyltransferase, rna cap binding, atp-binding, capsid protein, cleavage on pair of basic residues, endoplasmic reticulum, envelope protein, glycoprotein, helicase, hydrolase, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, transmembrane, viral nucleoprotein, virion, transferase |
由来する生物種 | Yellow fever virus |
細胞内の位置 | Capsid protein C: Virion (Potential). Peptide pr: Secreted. Small envelope protein M: Virion membrane; Multi-pass membrane protein (Potential). Envelope protein E: Virion membrane; Multi- pass membrane protein (Potential). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P03314 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 32198.40 |
構造登録者 | |
主引用文献 | Geiss, B.J.,Thompson, A.A.,Andrews, A.J.,Sons, R.L.,Gari, H.H.,Keenan, S.M.,Peersen, O.B. Analysis of flavivirus NS5 methyltransferase cap binding. J.Mol.Biol., 385:1643-1654, 2009 Cited by PubMed: 19101564DOI: 10.1016/j.jmb.2008.11.058 主引用文献が同じPDBエントリー |
実験手法 |
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