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3ETO

2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)

3ETO の概要
エントリーDOI10.2210/pdb3eto/pdb
分子名称Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
機能のキーワードalpha-beta sandwich, hd domain, lnr repeat, calcium-binding, sea domain, autoinhibition, activator, t-all, leukemia, oncogene, ank repeat, developmental protein, differentiation, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, receptor, transcription, transcription regulation, transmembrane, signaling protein
由来する生物種Homo sapiens
細胞内の位置Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531
タンパク質・核酸の鎖数2
化学式量合計54541.45
構造登録者
Gordon, W.R.,Blacklow, S.C. (登録日: 2008-10-08, 公開日: 2008-12-23, 最終更新日: 2023-09-06)
主引用文献Gordon, W.R.,Roy, M.,Vardar-Ulu, D.,Garfinkel, M.,Mansour, M.R.,Aster, J.C.,Blacklow, S.C.
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood, 113:4381-4390, 2009
Cited by
PubMed: 19075186
DOI: 10.1182/blood-2008-08-174748
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2 Å)
構造検証レポート
Validation report summary of 3eto
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-04-24に公開中

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