3ETO
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
3ETO の概要
エントリーDOI | 10.2210/pdb3eto/pdb |
分子名称 | Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total) |
機能のキーワード | alpha-beta sandwich, hd domain, lnr repeat, calcium-binding, sea domain, autoinhibition, activator, t-all, leukemia, oncogene, ank repeat, developmental protein, differentiation, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, receptor, transcription, transcription regulation, transmembrane, signaling protein |
由来する生物種 | Homo sapiens |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 54541.45 |
構造登録者 | |
主引用文献 | Gordon, W.R.,Roy, M.,Vardar-Ulu, D.,Garfinkel, M.,Mansour, M.R.,Aster, J.C.,Blacklow, S.C. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood, 113:4381-4390, 2009 Cited by PubMed: 19075186DOI: 10.1182/blood-2008-08-174748 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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