3ETA

Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

3ETA の概要

• エントリーDOI: 10.2210/pdb3eta/pdb
• 分子名称: insulin receptor, kinase domain, 1-(3-{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea (3 entities in total)
• 機能のキーワード: atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73363.77

構造登録者

Patnaik, S.,Stevens, K.,Gerding, R.,Deanda, F.,Shotwell, B.,Tang, J.,Hamajima, T.,Nakamura, H.,Leesnitzer, A.,Hassell, A.,Shewchuk, L.,Kumar, R.,Lei, H.,Chamberlain, S. (登録日: 2008-10-07, 公開日: 2009-05-26, 最終更新日: 2023-09-06)

• 主引用文献: Patnaik, S.,Stevens, K.L.,Gerding, R.,Deanda, F.,Shotwell, J.B.,Tang, J.,Hamajima, T.,Nakamura, H.,Leesnitzer, M.A.,Hassell, A.M.,Shewchuck, L.M.,Kumar, R.,Lei, H.,Chamberlain, S.D.; Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.; Bioorg.Med.Chem.Lett., 19:3136-3140, 2009; PubMed: 19394223; DOI: 10.1016/j.bmcl.2008.12.110

実験手法

X-RAY DIFFRACTION (2.6 Å)