3ESN

Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide

3ESN の概要

• エントリーDOI: 10.2210/pdb3esn/pdb
• 関連するPDBエントリー: 3ESO 3ESP
• 分子名称: Transthyretin, N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide (3 entities in total)
• 機能のキーワード: hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28352.87

構造登録者

Connelly, S.,Wilson, I.A. (登録日: 2008-10-06, 公開日: 2009-04-07, 最終更新日: 2023-12-27)

• 主引用文献: Johnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W.; Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.; J.Med.Chem., 52:1115-1125, 2009; PubMed: 19191553; DOI: 10.1021/jm801347s

実験手法

X-RAY DIFFRACTION (1.35 Å)