3ESJ

Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand

3ESJ の概要

• エントリーDOI: 10.2210/pdb3esj/pdb
• 分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, ... (6 entities in total)
• 機能のキーワード: mecdp-synthase, isoprene biosynthesis, lyase, magnesium, manganese, metal-binding
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18285.38

構造登録者

Hunter, W.N.,Ramsden, N.L. (登録日: 2008-10-06, 公開日: 2009-08-25, 最終更新日: 2023-11-01)

• 主引用文献: Ramsden, N.L.,Buetow, L.,Dawson, A.,Kemp, L.A.,Ulaganathan, V.,Brenk, R.,Klebe, G.,Hunter, W.N.; A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy; J.Med.Chem., 52:2531-2542, 2009; PubMed: 19320487; DOI: 10.1021/jm801475n

実験手法

X-RAY DIFFRACTION (2.7 Å)