3EQW

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in small unit cell

3EQW の概要

• エントリーDOI: 10.2210/pdb3eqw/pdb
• 関連するPDBエントリー: 1JPQ 1JRN 1L1H 3CE5 3EM2 3ERU 3ES0 3ET8
• 分子名称: 5'-D(*DGP*DGP*DGP*DGP*DTP*DTP*DTP*DTP*DGP*DGP*DGP*DG)-3', POTASSIUM ION, 3,6-Bis{3-[(2R)-(2-ethylpiperidino)]propionamido}acridine, ... (4 entities in total)
• 機能のキーワード: quadruplex, oxytricha nova, bsu-6042, bsu6042, anti-parallel, bimolecular, macromlecule, dna, g-quadruplex, telomere
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8311.06

構造登録者

Campbell, N.H.,Parkinson, G.,Neidle, S. (登録日: 2008-10-01, 公開日: 2008-10-14, 最終更新日: 2023-09-06)

主引用文献

Campbell, N.H.,Patel, M.,Tofa, A.B.,Ghosh, R.,Parkinson, G.N.,Neidle, S.
Selectivity in Ligand Recognition of G-Quadruplex Loops.
Biochemistry, 48:1675-1680, 2009

PubMed Abstract: A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.

PubMed: 19173611
DOI: 10.1021/bi802233v

実験手法

X-RAY DIFFRACTION (2.2 Å)