3EQM

Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione

Summary for 3EQM

Entry DOI	10.2210/pdb3eqm/pdb
Descriptor	Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total)
Functional Keywords	human aromatase, cytochrome p450, membrane protein, microsomal, estrogen, biosynthesis of steroid hormone, disease mutation, heme, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Peripheral membrane protein: P11511
Total number of polymer chains	1
Total formula weight	59047.70
Authors	Ghosh, D. (deposition date: 2008-10-01, release date: 2008-12-23, Last modification date: 2024-02-21)
Primary citation	Ghosh, D.,Griswold, J.,Erman, M.,Pangborn, W. Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature, 457:219-223, 2009 Cited by PubMed: 19129847 DOI: 10.1038/nature07614 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation