3EQB
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
3EQB の概要
エントリーDOI | 10.2210/pdb3eqb/pdb |
関連するPDBエントリー | 1S9I 1S9J 2P55 |
分子名称 | Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
機能のキーワード | protein kinase structure, mitogen activated protein kinase kinase, signal transduction, ligand co-complex, ternary co-complex with kinase, ligand and mgatp, non-competitive protein kinase inhibitor, transferase, acetylation, atp-binding, disease mutation, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37866.16 |
構造登録者 | |
主引用文献 | Warmus, J.S.,Flamme, C.,Zhang, L.Y.,Barrett, S.,Bridges, A.,Chen, H.,Gowan, R.,Kaufman, M.,Sebolt-Leopold, J.,Leopold, W.,Merriman, R.,Ohren, J.,Pavlovsky, A.,Przybranowski, S.,Tecle, H.,Valik, H.,Whitehead, C.,Zhang, E. 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18:6171-6174, 2008 Cited by PubMed: 18951019DOI: 10.1016/j.bmcl.2008.10.015 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.62 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード