3EQ6

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products

3EQ6 の概要

• エントリーDOI: 10.2210/pdb3eq6/pdb
• 関連するPDBエントリー: 3B7W 3C5E 3DAY
• 分子名称: Acyl-coenzyme A synthetase ACSM2A, ADENOSINE MONOPHOSPHATE, Butyryl Coenzyme A, ... (4 entities in total)
• 機能のキーワード: middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase, structural genomics, sgc, structural genomics consortium
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion matrix : Q08AH3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129038.81

構造登録者

Pilka, E.S.,Kochan, G.,Yue, W.W.,Bhatia, C.,Von delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Oppermann, U.,Structural Genomics Consortium (SGC) (登録日: 2008-09-30, 公開日: 2008-10-28, 最終更新日: 2023-11-01)

• 主引用文献: Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W.; Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A; J.Mol.Biol., 388:997-1008, 2009; PubMed: 19345228; DOI: 10.1016/j.jmb.2009.03.064

実験手法

X-RAY DIFFRACTION (2.4 Å)